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The IGF-system as a dominant effector of growth, metabolism and aging specifically impacts on normal and malignant growth, bone growth, fertility, muscle or fat accretion, re- or degeneration and thus life span and is a target for the treatment of many diseases including cancer. The IGF-system is constituted by insulin-like growth factors (IGF-I und –II), IGF-receptors, IGF-binding proteins (IGFBP-1 to -6) and IGFBP-proteases. IGFBPs are central determinants of the IGF actions.

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IGF Binding Proteins

IGFBPs – central biomarkers in vertebrates